+Pec Proteomics Research Group (+PPRG) - Biomedical Research Institute of Lleida (IRBLLEIDA) - Neuroscience Area – University Hospital Arnau de Vilanova (HUAV)

Xavier Gallart-Palau

Research field/topic: BioengineeringBiomarkers and DiagnosticsBody FluidsCardiovascularFood and NutritionNanotechnology/BioengineeringNeurology (Neuroscience)

Samples: BloodCell culture conditioned mediaPlantsTissuesUrineOther Biofluids

Isolation methods: Density gradientsImmunocaptureSECUltracentrifugation

Characterization techniques: Biomarker AnalysisBulk Flow CytometryElectron MicroscopyLipidomics and MetabolomicsMass spectometryNanoparticle Tracking AnalysisProteomics

Main research interest: The objective of +PPRG is to employ state-of-the-art techniques in clinical proteomics, mass spectrometry, and systems biology to uncover pathological molecular mechanisms that contribute to the onset and progression of various major diseases. We use chromatography and mass spectrometry, supported by cutting-edge equipment, to analyze and characterize proteins and metabolites involved in pathological processes, enabling a deeper understanding of molecular alterations. The group places special emphasis on investigating the pathological molecular mechanisms involved in intercellular communication, as well as identifying biomarkers with clinical prognostic capabilities.
At +PPRG, we prioritize translational research by exploring the potential of extracellular vesicles as an intercellular communication system and as biomarkers for diagnosis, stratification, and clinical prognosis. Additionally, we investigate the use of nanoparticles and vesicles as biocompatible nanovectors for the delivery of bioactive compounds and drugs in advanced therapeutic applications in personalized medicine.

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