This group was created following the first international conference of the recently created International Society of Extracellular Vesicles (ISEV), held in Goteborg (Sweden) in April 2012. The conference brought together more than 600 research groups worldwide, including some of the Spanish groups working in microvesicles. There, the Spanish researchers decided to form a working group to contribute to the dissemination and integration of these small vesicles in the field of clinical diagnosis in Spain.