November 3, 2020

Host Helminth interactions: In EVs we trust!

Dr Antonio Marcilla has participated in the great iniciative from ISEV: EVTalks. You can find this interesting talk at https://www.youtube.com/watch?v=Qm7TXfUz6IU

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September 23, 2020

Functional connection of EV secretion with mitophagy in melanoma cells

Dr María Yáñez-Mó has participated in the great iniciative from ISEV: EVTalks. You can find this interesting talk at https://www.youtube.com/watch?v=YVJn_Fcc-6Q

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September 8, 2020

The future of Extracellular Vesicles as Theranostics

The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic”, in which both Dr Marcilla and Dr Falcón-Perez participated. You can read in the recently published report, the interesting conclusions of […]

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September 8, 2020

Extracellular Vesicles in Metabolism

Dr Juan Manuel Falcón-Pérez has participated in the great iniciative from ISEV: EVTalks. You can find this interesting talk at https://www.youtube.com/watch?v=YVJn_Fcc-6Q

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August 17, 2020

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Moving forward in the use of EVs as disease biomarkers,  this seminal work published in Cell by the group of Dr Lyden with the contribution of Dr Hector Peinado.  Original article can be found here:  https://www.cell.com/cell/fulltext/S0092-8674(20)30874-6

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June 3, 2020

Extracellular vesicles play an important role in the pathology of malaria vivax

Plasmodium vivax is the most widely distributed human malaria parasite, mostly outside sub-Saharan Africa, and responsible for millions of clinical cases yearly, including severe disease and death. The mechanisms by which P. vivax causes disease are not well understood. Recent evidence suggests that, similar to what has been observed with the more lethal P. falciparum, red blood cells infected […]

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June 3, 2020

Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant/Hypertrophied Adiposomes

Un posible marcador da obesidade nas vesículas extracelulares Científicos do IDIS de Santiago conclúen que as vesículas liberadas por adipocitos obesos e diabéticos inducen estas patoloxías en adipocitos sans. O redescubrimento das vesículas extracelulares (pequenas estruturas liberadas por todas as células do organismo), debido ao papel tan importante que xogan tanto nos procesos fisiolóxicos normais como en […]

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June 2, 2020

Regulation of MT1-MMP Activity through Its Association with ERMs and tetraspanins

Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorporation into tetraspanin-enriched microdomains (TEMs), into invadopodia, or by its secretion on extracellular vesicles (EVs). We […]

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June 2, 2020

MiR-219a-5p enriched extracellular vesicles induce OPC differentiation and EAE improvement more efficiently than liposomes and polymeric nanoparticles.

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell […]

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