News & Publications

A Rapid, Convergent Approach to the Identification of Exosome Inhibitors in Breast Cancer Models

The group of Dr Vicent describe a rapid, convergent, and cost-efficient strategy to analyze candidate U.S. Food and Drug Administration (FDA)-approved drugs that inhibit exosome release and/or biogenesis using breast cancer cell line models in the hope of repurposing them for the clinical treatment of metastatic tumors based on AlphaScreenTM technology The manuscript is available at […]

N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV–Cell Interaction and Functional Activation of Endothelial Cells

A collaborative work from Dr Borrás´s and Dr Falcón-Perez groups demonstrating the functional relevance of N-Glycans on the surface of EVs. The manuscript is available at https://www.mdpi.com/1422-0067/23/17/9539

El Biobanco del Fundación Instituto Valenciano de Oncología (IVO), el primero en España en obtener la Acreditación internacional ISO20387

El biobanco de la Fundación Instituto Valenciano de Oncología (IVO), ha sido el primero en España en obtener la acreditación internacional ISO20387: una norma que avala la gestión de la calidad del material biológico, de las muestras de control y los datos obtenidos para la investigación biomédica. Para el jefe de servicio del laboratorio de […]

Bioimplants with extra-cellular vesicles from stem cells can improve cardiac function after an acute myocardial heart attack

Researchers from the ICREC Group (Cardiac Insufficiency and Regeneration in cardiovascular diseases) at the Germans Trias i Pujol Research Institute (IGTP) continue to work on therapeutic technologies to repair cardiac tissue after a heart attack in collaboration with the IVECAT group (IGTP). In an article published in Theranostics, they present a study of extracellular vesicles […]

Overall Survival and Biomarker Analysis of Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non–Small-Cell Lung Cancer

Te group of Dr Atocha Romero has just published the terrific results of the NADIM phase II trial, showing that ctDNA levels were significantly associated with OS and outperformed radiologic assessments in the prediction of survival. The manuscript is available at https://ascopubs.org/doi/full/10.1200/JCO.21.02660#.YoK7H6Useqs.twitter

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis

A new piece of work from Dr Peinado´s group in which the medical oncologist Alberto Carretero, co-supervised with Guillermo De Velasco Oria de Rueda and Marta Herguetas characterize in depth circulating EVs from patients with brain metastasis. The manuscript is available at

Commonly used methods for extracellular vesicles’ enrichment: Implications in downstream analyses and use

As part of the Special Issue on EVs at the European Journal of Cell Biology, Marta Clos-San Salvador and Marta Monguió-Tortajada from Dr Borrás´s group (REMAR-IVECAT Research Group (Kidney Related Pathologies Research Group – Innovation in Vesicles and Cells for Application in Therapy) at IGTP (Germans Trias i Pujol Health Sciences Research Institute)) nicely update […]

ALK-Fusion Transcripts Can Be Detected in Extracellular Vesicles (EVs) from Nonsmall Cell Lung Cancer Cell Lines and Patient Plasma: Toward EV-Based Noninvasive Testing

A great work from the group of Dr Mariano Provencio and Dr Atocha Romero in collaboration with other TeNTaCLES members Dr Valés-Gómez and Dr Pardo. The manuscript is freely available to the scientific community at https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvac021/6554744#.YkH0kcWcq1s.whatsapp

The TeNTaCLES project funds two ESR mobilities in collaboration with GEIVEX