Publications

Regulation of MT1-MMP Activity through Its Association with ERMs and tetraspanins

Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorporation into tetraspanin-enriched microdomains (TEMs), into invadopodia, or by its secretion on extracellular vesicles (EVs). We […]

MiR-219a-5p enriched extracellular vesicles induce OPC differentiation and EAE improvement more efficiently than liposomes and polymeric nanoparticles.

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell […]

ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19

Two members of GEIVEX board: Dr Falcón-Pérez and Dr Borrás, have participated in the discussion that lead to the joint statement of ISEV and ISCT on the use of EVs on COVID-19. STATEMENT: The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular […]

Polarized Sorting of Patched Enables Cytoneme-Mediated Hedgehog Reception in the Drosophila Wing Disc

The group of Isabel Guerrero at CBM-SO, has recently described how Hedgehog (Hh) signal molecules, which play a fundamental role in development, adult stem cell maintenance and cancer, can signal at a distance via a graded distribution across Drosophila epithelia that is mediated by filopodia-like structures called cytonemes. Hh reception by Patched (Ptc) happens at […]

Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant/Hypertrophied Adiposomes

Un posible marcador da obesidade nas vesículas extracelulares Científicos do IDIS de Santiago conclúen que as vesículas liberadas por adipocitos obesos e diabéticos inducen estas patoloxías en adipocitos sans. O redescubrimento das vesículas extracelulares (pequenas estruturas liberadas por todas as células do organismo), debido ao papel tan importante que xogan tanto nos procesos fisiolóxicos normais como en […]

Role of EVs in ROS activity and Endothelial cell senescence

The group of Dr. Rafael Ramírez from the Universidad de Alcalá, have recently published 2 interesting papers on the role of ROS and endothelial cell senescence with important implications in aging and disease. You can read more here and here

Review on EV-mediated communication in Glioblastoma

Dr. Matarredona and Dr. Pastor have recently published this interesting review about the communication  between Glioblastoma and its microenvironment mediated by EVs and their cargo You can read more here.

Development of a quantitative method to measure EV uptake

Study of Vesicular and Non-Vesicular miRNAs from Cerebrospinal Fluid