Plasmodium vivax is the most widely distributed human malaria parasite, mostly outside sub-Saharan Africa, and responsible for millions of clinical cases yearly, including severe disease and death. The mechanisms by which P. vivax causes disease are not well understood. Recent evidence suggests that, similar to what has been observed with the more lethal P. falciparum, red blood cells infected […]
Read MoreMembrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorporation into tetraspanin-enriched microdomains (TEMs), into invadopodia, or by its secretion on extracellular vesicles (EVs). We […]
Read MoreRemyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell […]
Read MoreTwo members of Tentacles: Dr Falcón-Pérez and Dr Borrás, have participated in the discussion that lead to the joint statement of ISEV and ISCT on the use of EVs on COVID-19. STATEMENT: The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles […]
Read MoreTwo members of GEIVEX board: Dr Falcón-Pérez and Dr Borrás, have participated in the discussion that lead to the joint statement of ISEV and ISCT on the use of EVs on COVID-19. STATEMENT: The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular […]
Read MoreThe group of Isabel Guerrero at CBM-SO, has recently described how Hedgehog (Hh) signal molecules, which play a fundamental role in development, adult stem cell maintenance and cancer, can signal at a distance via a graded distribution across Drosophila epithelia that is mediated by filopodia-like structures called cytonemes. Hh reception by Patched (Ptc) happens at […]
Read MoreUn posible marcador da obesidade nas vesículas extracelulares Científicos do IDIS de Santiago conclúen que as vesículas liberadas por adipocitos obesos e diabéticos inducen estas patoloxías en adipocitos sans. O redescubrimento das vesículas extracelulares (pequenas estruturas liberadas por todas as células do organismo), debido ao papel tan importante que xogan tanto nos procesos fisiolóxicos normais como en […]
Read MoreThe malaria parasite Plasmodium vivax can adhere to human spleen cells through the expression of so-called variant proteins. These are the conclusions of a study led by the Barcelona Institute for Global health (ISGlobal), an institution supported by “la Caixa” and the Germans Trias i Pujol Research Institute (IGTP). The results, published in PNAS, suggest that this could […]
Read MoreUn proyecto del IGTP desarrolla un test rápido, barato y efectivo para monitorizar el grado de fibrosis del riñón trasplantado https://www.lavanguardia.com/ciencia/20200518/481150903605/preguntas-big-vang-fibrosis-renal-trasplante-rinon-biomarcador-no-invasivo-francesc-borras-igtp.html
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